Charles V, Holy Roman Emperor
| Reign | January 23, 1516 - January 16, 1556 (39 years) (as King of Spain) |
| Coronation | March 14, 1516 (as King of Spain) |
| Co-Monarch | Joanna, Queen of Aragon and Castile |
| Predecessor |
Ferdinand II of Aragon/V of Castile Joanna, Queen of Aragon and Castile |
| Successor | Philip II of Spain |
| House | House of Habsburg |
| Birth |
February 24, 1500 Ghent, Belgium |
| Father | Philip I of Castile (1478-1506) |
| Mother | Joanna, Queen of Aragon and Castile (1479-1555) |
| Brothers | Ferdinand I, Holy Roman Emperor (1503-1564) |
| Sisters |
Eleanor, Queen of France (1498-1558) Isabella, Queen of Denmark (1501-1526) Mary, Queen of Hungary (1505-1558) Catherine, Queen of Portugal (1507-1578) |
| Paternal Grandparents |
Maximilian I, Holy Roman Emperor (1459-1519) Mary, Duchess of Burgundy (1457-1482) |
| Maternal Grandparents |
Ferdinand II of Aragon/V of Castile (1452-1516) Isabella I of Castile (1451-1504) |
| Death |
September 21, 1558 Yuste, Spain (58 years) |
| Isabella, Infanta of Portugal (1503-1539) |
Married March 10, 1526 Widowed May 1, 1539 (13 years) |
|
(m.1543 Maria Manuela, Infanta of Portugal) (1 son) (m.1554 Mary I of England) (m.1559 Elisabeth, Princess of Valois) (2 daughters) (m.1570 Anna, Archduchess of Austria) (4 sons, 1 daughter) |
Born May 21, 1527 Died September 13, 1598 (72 years) |
|
Maria, Archduchess of Austria (m.1548 Maximilian II, Holy Roman Emperor) (9 sons, 6 daughters) |
Born June 21, 1528 Died February 26, 1603 (74 years) |
| Ferdinand, Archduke of Austria |
Born 1529 Died 1533 (4 years) |
|
Joanna, Archduchess of Austria (m.1552 Joao Manuel, Infante of Portugal) (1 son) |
Born June 24, 1535 Died September 7, 1573 (38 years) |
| John, Archduke of Austria |
Born 1537 Died 1537 (1 day) |